Exogenous IgE acts as an adjuvant in tumor vaccination in mice, and therefore a direct role of endogenous IgE in tumor immunosurveillance was investigated. By using genetically engineered mice, we found that IgE ablation rendered mice more susceptible to the growth of transplantable tumors. Conversely, a strengthened IgE response provided mice with partial or complete resistance to tumor growth, depending on the tumor type. By genetic crosses, we showed that IgE-mediated tumor protection was mostly lost in mice lacking FceRI. Tumor protection was also lost after depletion of CD8+ T cells, highlighting a cross-Talk between IgE and T cell- mediated tumor immunosurveillance. Our findings provide the rationale for clinical observations that relate atopy with a lower risk for developing cancer and open new avenues for the design of immunotherapeutics relevant for clinical oncology. The Journal of Immunology, 2016, 197: 2583-2588.
Cutting edge : IgE plays an active role in tumor immunosurveillance in mice / E.A. Nigro, A.T. Brini, V.A. Yenagi, L.M. Ferreira Espinoza, G. Achatz Straussberger, A. Ambrosi, F. Sanvito, E. Soprana, E. Van Anken, G. Achatz, A.G. Siccardi, L. Vangelista. - In: JOURNAL OF IMMUNOLOGY. - ISSN 0022-1767. - 197:7(2016), pp. 2583-2588.
|Titolo:||Cutting edge : IgE plays an active role in tumor immunosurveillance in mice|
BRINI, ANNA TERESA (Secondo)
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
Settore BIO/13 - Biologia Applicata
|Data di pubblicazione:||2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.4049/jimmunol.1601026|
|Appare nelle tipologie:||01 - Articolo su periodico|