Obesity plays relevant pathophysiological role in the development of health problems, arising as result of complex interaction of genetic, nutritional, and metabolic factors. Due to the role of adipose tissue in lipid and glucose metabolism, and low grade inflammation, it is necessary to classify obesity on the basis of body fat composition and distribution, rather than the simply increase of body weight, and the Body Mass Index. The new term of adiposopathy ("sick fat") clearly defines the pathogenic role of adipose tissue. Four phenotypes of obese individuals have been described: (1) normal weight obese (NWO); (2) metabolically obese normal weight; (3) metabolically healthy obese; and (4) metabolically unhealthy obese or "at risk" obese. Moreover, sarcopenic obesity has been related to all the phenotypes. The category of normal weight lean, represented by metabolically healthy normal weight has been classified to distinguish from NWO. It is crucial to recommend a bariatric surgery taking into account adiposopathy and sick fat that occurs with the expansion of fat mass, changing the inflammatory and metabolic profile of the patient. Body fat percentage and genetic polymorphism have to be evaluated to personalize the best bariatric surgery intervention. © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.

New obesity classification criteria as a tool for bariatric surgery indication / A. De Lorenzo, L. Soldati, F. Sarlo, M. Calvani, N. Di Lorenzo, L. Di Renzo. - In: WORLD JOURNAL OF GASTROENTEROLOGY. - ISSN 1007-9327. - 22:2(2016 Jan 14), pp. 681-703.

New obesity classification criteria as a tool for bariatric surgery indication

L. Soldati;
2016

Abstract

Obesity plays relevant pathophysiological role in the development of health problems, arising as result of complex interaction of genetic, nutritional, and metabolic factors. Due to the role of adipose tissue in lipid and glucose metabolism, and low grade inflammation, it is necessary to classify obesity on the basis of body fat composition and distribution, rather than the simply increase of body weight, and the Body Mass Index. The new term of adiposopathy ("sick fat") clearly defines the pathogenic role of adipose tissue. Four phenotypes of obese individuals have been described: (1) normal weight obese (NWO); (2) metabolically obese normal weight; (3) metabolically healthy obese; and (4) metabolically unhealthy obese or "at risk" obese. Moreover, sarcopenic obesity has been related to all the phenotypes. The category of normal weight lean, represented by metabolically healthy normal weight has been classified to distinguish from NWO. It is crucial to recommend a bariatric surgery taking into account adiposopathy and sick fat that occurs with the expansion of fat mass, changing the inflammatory and metabolic profile of the patient. Body fat percentage and genetic polymorphism have to be evaluated to personalize the best bariatric surgery intervention. © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
adiposopathy; fat mass; laparoscopic gastric banding; metabolically healthy normal weight; metabolically healthy obese; metabolically obese normal weight; metabolically unhealthy obese; normal weight lean; normal weight obese; obesity
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
14-gen-2016
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/449862
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