Epilessia e morbo di Wilson: discussione di un caso clinico e revisione della letteratura = Epilepsy and Wilson's disease: case report and literature review

We describe the case of a 26 years old patient, with neuro-psychiatric onset of Wilson's disease, who developed severe generalized dystonia, dysphagia and dysphonia, two weeks after introducing Penicillamine treatment. Brain MRI showed extensive damage of cerebral white matter and cortex in temporal lobes, basal ganglia, thalamus and brainsteam. Despite of treatment was shifted to Trientine and Zinc Acetate, there was not clinical improvement and a month later the patient presented a status epilepticus. In addition a new MRI showed an important extension of temporal lesions.