Background/Aims: The aim of this study was to analyze the outcome of 33 patients with primary gastrointestinal stromal tumors (GISTs) who were observed and treated in a single teaching hospital and followed up prospectively. Methodology: Thirty-three GISTs patients (21 male; 12 female; mean age: 57±12 years; range: 23-76 years) between June 1994 and October 2004, were reviewed retrospectively. Patient, tumor, and treatment variables were analyzed to identify patterns of tumor relapse and factors affecting survival. Results: Of 33 patients, 30 patients (91%) had primary tumor without metastasis, and all of them underwent complete surgical resection of gross disease. Three patients (9%) had metastasis. Among patients radically resected, the 5-year actuarial survival rate was 85%, and the disease-free survival was 76%. Among patients resected for cure, there were 6 recurrences. The mean time to recurrence was 22±11 months (range: 4-36 months), and liver was the prevalent site for relapsing disease (n=5; 83%). After recurrence, survival at 2 and 3 years was 44% and 0%, respectively. Conclusions: GISTs are uncommon sarcomas. Tumor recurrence tends to be intra-abdominal. Investigational protocols are indicated to reduce the rate of recurrence after resection and to improve the outcome for patients with GIST.
Prognostic factors and outcome of resected patients for gastrointestinal stromal tumors / A. Chiappa, A.P. Zbar, R. Biffi, E. Bertani, U. Pace, G. PRUNERI, G. Viale, P. Della Vigna, C. Grassi, M. Valerio, D. Poldi, B. Andreoni. - In: HEPATO-GASTROENTEROLOGY. - ISSN 0172-6390. - 54:75(2007), pp. 693-696.
Prognostic factors and outcome of resected patients for gastrointestinal stromal tumors
A. ChiappaPrimo
;G. PRUNERI;G. Viale;B. AndreoniUltimo
2007
Abstract
Background/Aims: The aim of this study was to analyze the outcome of 33 patients with primary gastrointestinal stromal tumors (GISTs) who were observed and treated in a single teaching hospital and followed up prospectively. Methodology: Thirty-three GISTs patients (21 male; 12 female; mean age: 57±12 years; range: 23-76 years) between June 1994 and October 2004, were reviewed retrospectively. Patient, tumor, and treatment variables were analyzed to identify patterns of tumor relapse and factors affecting survival. Results: Of 33 patients, 30 patients (91%) had primary tumor without metastasis, and all of them underwent complete surgical resection of gross disease. Three patients (9%) had metastasis. Among patients radically resected, the 5-year actuarial survival rate was 85%, and the disease-free survival was 76%. Among patients resected for cure, there were 6 recurrences. The mean time to recurrence was 22±11 months (range: 4-36 months), and liver was the prevalent site for relapsing disease (n=5; 83%). After recurrence, survival at 2 and 3 years was 44% and 0%, respectively. Conclusions: GISTs are uncommon sarcomas. Tumor recurrence tends to be intra-abdominal. Investigational protocols are indicated to reduce the rate of recurrence after resection and to improve the outcome for patients with GIST.Pubblicazioni consigliate
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