Peripheral benzodiazepine (BDZ) receptors were investigated by means of the binding of the specific ligand (3)H-PK 11195 to platelet membranes in patients suffering from bipolar disorder and in healthy controls. The results showed that the density (Bmax) of peripheral BDZ receptors was significantly higher in patients than in control subjects, with no change in the dissociation constant. No correlation with demographic or clinical features was observed. These findings would suggest that alterations of peripheral BDZ receptors are present in patients suffering from bipolar disorder, but it is premature to conclude whether they may be related to the pathophysiology of the disorder, or are secondary to changes occurring in other systems, such as those regulating the stress response.
Changes in peripheral benzodiazepine receptors in patients with bipolar disorder / D. Marazziti, B. Dell'Osso, S. Baroni, I. Masala, E.D. Nasso, G. Giannaccini, L. Dell'Osso. - In: NEUROPSYCHIATRIC DISEASE AND TREATMENT. - ISSN 1176-6328. - 1:2(2005 Jun), pp. 151-154.
Changes in peripheral benzodiazepine receptors in patients with bipolar disorder
B. Dell'OssoSecondo
;
2005
Abstract
Peripheral benzodiazepine (BDZ) receptors were investigated by means of the binding of the specific ligand (3)H-PK 11195 to platelet membranes in patients suffering from bipolar disorder and in healthy controls. The results showed that the density (Bmax) of peripheral BDZ receptors was significantly higher in patients than in control subjects, with no change in the dissociation constant. No correlation with demographic or clinical features was observed. These findings would suggest that alterations of peripheral BDZ receptors are present in patients suffering from bipolar disorder, but it is premature to conclude whether they may be related to the pathophysiology of the disorder, or are secondary to changes occurring in other systems, such as those regulating the stress response.File | Dimensione | Formato | |
---|---|---|---|
marazziti et al, 2005.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
55.69 kB
Formato
Adobe PDF
|
55.69 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.