Aims: To evaluate Compass, a new instrument for glaucoma screening and diagnosis that combines scanning ophthalmoscopy, automated perimetry, and eye tracking. Materials and Methods: A total of 320 human subjects (200 normal, 120 with glaucoma) underwent full ophthalmological evaluation and perimetric evaluation using the Humphrey SITA standard 24° test (HFA), and the Compass test that consisted of a full-threshold program on the central 24°with a photograph of the central 30° of the retina. A subgroup of normal subjects and glaucoma patients underwent a second Compass test during the same day in order to study test-retest variability. After exclusion of 30 patients due to protocol rules, a database was created to compare the Compass to the HFA, and to evaluate retinal image quality and fixation stability. Results: The difference inmean sensitivity between Compass and HFA was -1.02 ± 1.55 dB in normal subjects (p<0.001) and -1.01 ± 2.81 dB in glaucoma (p<0.001). Repeatability SD for the average sensitivity was 1.53 for normal subjects and 1.84 for glaucoma. Test time with the Compass was 634±96 s (607±78 for normals, 678±108 for glaucoma). Compass analysis showed the percentage of fixation within the central 1° was 86.6%in normal subjects, and 79.3%in glaucoma patients. Color image quality was sufficient for diagnostic use in >65% of cases; Image-based diagnosis was in accordance with the initial diagnosis in 85%of the subjects. Conclusions: Based on preliminary results, Compass showed useful diagnostic characteristics for the study of glaucoma, and combined morphological information with functional data.
Compass : clinical evaluation of a new instrument for the diagnosis of glaucoma / L. Rossetti, M. Digiuni, A. Rosso, R. Riva, G. Barbaro, M.K. Smolek, N. Orzalesi, S. De Cilla, A. Autelitano, P. Fogagnolo. - In: PLOS ONE. - ISSN 1932-6203. - 10:3(2015), pp. e0122157.1-e0122157.14.
|Titolo:||Compass : clinical evaluation of a new instrument for the diagnosis of glaucoma|
ROSSETTI, LUCA MARIO (Primo)
DIGIUNI, MAURIZIO (Secondo)
AUTELITANO, ALESSANDRO (Penultimo)
FOGAGNOLO, PAOLO (Ultimo)
|Parole Chiave:||Adult; Aged; Aged, 80 and over; Algorithms; Automation; Databases, Factual; Female; Glaucoma; Humans; Male; Middle Aged; Ophthalmoscopy; Visual Field Tests; Visual Fields; Agricultural and Biological Sciences (all); Biochemistry, Genetics and Molecular Biology (all); Medicine (all)|
|Settore Scientifico Disciplinare:||Settore MED/30 - Malattie Apparato Visivo|
|Data di pubblicazione:||2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1371/journal.pone.0122157|
|Appare nelle tipologie:||01 - Articolo su periodico|