Cytogenetic and p53 mutation analysis in two cases of severe dysplasia of the bronchial epithelium in lung cancer patients and p53 immunostaining in a third one are reported. The finding of both chromosomal deletions of 17p and p53 mutation indicates that these changes may take place early in the process of lung carcinogenesis.
Deletions of 17p and p53 Mutations in Preneoplastic Lesions of the Lung / G. Sozzi, M. Miozzo, R. Donghi, S. Pilotti, C.T. Cariani, U. Pastorino, G. Delia Porta, M.A. Pierotti. - In: CANCER RESEARCH. - ISSN 0008-5472. - 52:21(1992 Nov), pp. 6079-6082.
Deletions of 17p and p53 Mutations in Preneoplastic Lesions of the Lung
M. MiozzoSecondo
;
1992
Abstract
Cytogenetic and p53 mutation analysis in two cases of severe dysplasia of the bronchial epithelium in lung cancer patients and p53 immunostaining in a third one are reported. The finding of both chromosomal deletions of 17p and p53 mutation indicates that these changes may take place early in the process of lung carcinogenesis.
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