During development, many neurons display calcium- dependent migration, but the role of this messenger in regulating gene expression leading to this event has not yet been elucidated. Among the decoders of calcium signals is calcineurin, a Ca2 / calmodulin serine/threonine phosphatase that has been involved in both short-term and long-term cellular changes. By using immortalized GnRH-secreting neurons, we now show that, in vitro, Ca2 - dependent gene expression, proceeding via calcineurin and the transcription factor nuclear factor of activated T cells, is a key player controlling the chemomigratory potential of developing GnRH-secreting neurons. Furthermore, our data highlight the switch nature of this phosphatase, whose activation or inactivation guides cells to proceed from one genetic program to the next

Calcineurin primes immature gonadotropin-releasing hormone-secreting neuroendocrine cells for migration / R. Zaninetti, S. Tacchi, J. Erriquez, C. Distasi, R. Maggi, A. Cariboni, F. Condorelli, P.L. Canonico, A.A. Genazzani. - In: MOLECULAR ENDOCRINOLOGY. - ISSN 0888-8809. - 22:3(2008), pp. 729-736. [10.1210/me.2007-0277]

Calcineurin primes immature gonadotropin-releasing hormone-secreting neuroendocrine cells for migration

R. Maggi;A. Cariboni;
2008

Abstract

During development, many neurons display calcium- dependent migration, but the role of this messenger in regulating gene expression leading to this event has not yet been elucidated. Among the decoders of calcium signals is calcineurin, a Ca2 / calmodulin serine/threonine phosphatase that has been involved in both short-term and long-term cellular changes. By using immortalized GnRH-secreting neurons, we now show that, in vitro, Ca2 - dependent gene expression, proceeding via calcineurin and the transcription factor nuclear factor of activated T cells, is a key player controlling the chemomigratory potential of developing GnRH-secreting neurons. Furthermore, our data highlight the switch nature of this phosphatase, whose activation or inactivation guides cells to proceed from one genetic program to the next
neuron ; calcium ; migration ; GnRH
Settore BIO/09 - Fisiologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/44430
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