The continuous flow synthesis of a series of amines was successfully achieved by exploiting the enhanced stability and broad substrate scope of an immobilised transaminase from Halomonas elongata (HEWT). A series of substrates were tested in flow reactors and transformed into the corresponding amines in good to excellent yields. The process was implemented with an integrated in-line purification step for the recovery of the pure amines.

Continuous flow biocatalysis : production and in-line purification of amines by immobilised transaminase from Halomonas elongata / M. Planchestainer, M.L. Contente, J. Cassidy, F. Molinari, L. Tamborini, F. Paradisi. - In: GREEN CHEMISTRY. - ISSN 1463-9262. - 19:2(2017 Jan 21), pp. 372-375. [10.1039/C6GC01780K]

Continuous flow biocatalysis : production and in-line purification of amines by immobilised transaminase from Halomonas elongata

M.L. Contente;F. Molinari;L. Tamborini;
2017-01-21

Abstract

The continuous flow synthesis of a series of amines was successfully achieved by exploiting the enhanced stability and broad substrate scope of an immobilised transaminase from Halomonas elongata (HEWT). A series of substrates were tested in flow reactors and transformed into the corresponding amines in good to excellent yields. The process was implemented with an integrated in-line purification step for the recovery of the pure amines.
Settore CHIM/11 - Chimica e Biotecnologia delle Fermentazioni
Settore CHIM/08 - Chimica Farmaceutica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/444290
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