The objective of this study was to investigate the possibility of visualizing the ability of hydroxypropylmethylcellulose (HPMC) and a nasal spray (First Defense), in which the bioadhesive is HPMC, to bind to human mucosal cells using inorganic (black carbon particles and Congo red dye) and organic markers (Escherichia coli). A significant reduction in the bacterial adhesiveness has been observed. Our findings indicate the possibility of counteracting the lock-and-key mechanism of microorganism adhesion using the bioadhesive properties of polymers, such as HPMC, in First Defense to prevent a possible contact between adhesins and complementary receptors.
Visual evaluation of binding to mucosal cells of a medical device against the common cold / P. Braga, M. Dal Sasso, M. Culici. - In: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. - ISSN 0363-9045. - 34:5(2008 May), pp. 459-464. [10.1080/03639040701657909]
Visual evaluation of binding to mucosal cells of a medical device against the common cold
P. BragaPrimo
;
2008
Abstract
The objective of this study was to investigate the possibility of visualizing the ability of hydroxypropylmethylcellulose (HPMC) and a nasal spray (First Defense), in which the bioadhesive is HPMC, to bind to human mucosal cells using inorganic (black carbon particles and Congo red dye) and organic markers (Escherichia coli). A significant reduction in the bacterial adhesiveness has been observed. Our findings indicate the possibility of counteracting the lock-and-key mechanism of microorganism adhesion using the bioadhesive properties of polymers, such as HPMC, in First Defense to prevent a possible contact between adhesins and complementary receptors.Pubblicazioni consigliate
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