The objective of this study was to investigate the possibility of visualizing the ability of hydroxypropylmethylcellulose (HPMC) and a nasal spray (First Defense), in which the bioadhesive is HPMC, to bind to human mucosal cells using inorganic (black carbon particles and Congo red dye) and organic markers (Escherichia coli). A significant reduction in the bacterial adhesiveness has been observed. Our findings indicate the possibility of counteracting the lock-and-key mechanism of microorganism adhesion using the bioadhesive properties of polymers, such as HPMC, in First Defense to prevent a possible contact between adhesins and complementary receptors.
|Titolo:||Visual evaluation of binding to mucosal cells of a medical device against the common cold|
|Autori interni:||BRAGA, PIERCARLO (Primo)|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||mag-2008|
|Digital Object Identifier (DOI):||10.1080/03639040701657909|
|Appare nelle tipologie:||01 - Articolo su periodico|