The risk of developing renal cell carcinoma (RCC) increases with age, and given the constant gain in life expectancy of the general population, both localized RCC and metastatic RCC (mRCC) are more frequently observed in the elderly population. The elderly are a heterogeneous group of patients often characterized by the presence of comorbidities, different compliance to treatment and polypharmacy. Here we review the available data with the aim to analyze the safety and efficacy of new targeted therapies (TTs) in elderly mRCC patients. TTs seem to be effective in both older and younger patients, but elderly patients appear to show reduced tolerance to treatments compared to younger patients. Prospective trials are needed to better understand how to manage mRCC in elderly patients.

Treatment of elderly patients with metastatic renal cell carcinoma / E. Zanardi, P. Grassi, A. Cavo, E. Verzoni, C. Maggi, F. De Braud, F. Boccardo, G. Procopio. - In: EXPERT REVIEW OF ANTICANCER THERAPY. - ISSN 1473-7140. - 16:3(2016 Jan), pp. 323-334. [10.1586/14737140.2016.1131613]

Treatment of elderly patients with metastatic renal cell carcinoma

E. Verzoni;C. Maggi;F. De Braud;
2016-01

Abstract

The risk of developing renal cell carcinoma (RCC) increases with age, and given the constant gain in life expectancy of the general population, both localized RCC and metastatic RCC (mRCC) are more frequently observed in the elderly population. The elderly are a heterogeneous group of patients often characterized by the presence of comorbidities, different compliance to treatment and polypharmacy. Here we review the available data with the aim to analyze the safety and efficacy of new targeted therapies (TTs) in elderly mRCC patients. TTs seem to be effective in both older and younger patients, but elderly patients appear to show reduced tolerance to treatments compared to younger patients. Prospective trials are needed to better understand how to manage mRCC in elderly patients.
elderly; geriatric oncology; mRCC; renal cell carcinoma; targeted therapy; pharmacology (medical); oncology
Settore MED/06 - Oncologia Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/442761
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