Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.
A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis : A EUSTAR exploratory study / F. Ingegnoli, P. Boracchi, R. Gualtierotti, V. Smith, M. Cutolo, I. Foeldvari, P. Airo, J.J. Alegre-Sancho, Y. Allanore, L.P. Ananieva, C. Ancuta, L.E. Andrade, M. Aringer, R. Becvar, M. Bojinca, I. Butrimiene, F.P. Cantatore, R. Caporali, P. Caramaschi, P.E. Carreira, R. Chirieac, A. Corrado, V. Cosentino, G. Cuomo, L. Czirjak, J.A.P. Da Silva, P.G. de la Pena Lefebvre, F. De Keyser, C. de Souza Muller, K. Damgaard, N. Damjanov, L.N. Denisov, O. Distler, A. Doube, A. Dumitrascu, M. Engelhart, M.V. Exposito, K. Eyerich, D. Farge-Bancel, V.F. Azevedo, R. Foti, M. Frerix, A. Gabrielli, T. Garen, P. Gottschalk, L. Groseanu, S. Guiducci, C. Gunther, E. Hachulla, R. Hein, S. Heitmann, J. Henes, R. Hesselstrand, J. Highton, F. Iannone, R.M. Ionescu, C. Kayser, D. Karpec, E. Kerzberg, A. Kotulska, M. Kopec-Medrek, E. Kucharz, B. Krummel-Lorenz, F. Lauffer, D. Launay, M. Li, I. Litinsky, E. Loyo, M.M. Cerinic, P. Meroni, O. Midtvedt, C.M. Mihai, C. Montecucco, F. Montoya, E. Morgiel, L. Mouthon, U. Muller-Ladner, H. Nielsen, D. Opris, V. Ortiz-Santamaria, K. Otsa, M. Pileckyte, S. Pisarri, M. Popescu, M.R. Pozzi, F. Puppo, S.C. Radominski, V. Riccieri, E. Rosato, B. Rozman, S.R. Rubio, R. Rugiene, P. Saar, M.J. Salvador, M. Seidel, R. Sokolik, K. Solanki, B. Stamenkovic, A. Stankovic, S. Stebbings, G. Strauss, A. Sulli, S. Szamosi, J. Szechinski, M. Szmyrka-Kaczmarek, G. Szucs, C.-. Tanaseanu, I. Tiglea, A. Tyndall, N. Ughi, M. Uprus, A. Vacca, C. Varju, A. Venalis, P. Venalis, U.A. Walker, M. Widuchowska, P. Wiland, D. M. Wuttge, S. Zeni, T. Zenone. - In: MICROVASCULAR RESEARCH. - ISSN 0026-2862. - 102(2015 Nov), pp. 19-24. [10.1016/j.mvr.2015.07.007]
A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis : A EUSTAR exploratory study
F. Ingegnoli;P. Boracchi;R. Gualtierotti;R. CaporaliMembro del Collaboration Group
;A.M. CARVALHAS GABRIELLI;F. Iannone;M. Li;M.R. Pozzi;N. Ughi;
2015
Abstract
Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.
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