We investigated the effects of maternal exposure to the plasticizer di(2-ethylhexyl) phthalate (DEHP) and the organic industrial compounds polychlorinated biphenyls (PCBs), singly and combined, on the reproductive function of male mouse offspring. Mice dams were exposed throughout pregnancy and lactation to 1 mu g PCBs (101 +118)/kg/day, 50 mu g DEHP/kg/day, or the DEHP/PCB mixture in the diet. The mixture induced permanent alterations in adult F1 males' reproductive health in a way, differently from the single compounds. Depending on the endpoint, we observed: (1) synergy in altering the gross and histological morphology of the testis; (2) antagonism on the expression levels of genes involved in pituitary-gonadal cross-talk; (3) non-interactions on sperm parameters and testosterone production. This study illustrates the complex action of a DEHP/PCB mixture, leading to a unique panel of effects on the male reproductive system, indicating the need for research on the reproductive hazards of combined endocrine disruptors.
Maternal exposure to a mixture of di(2-ethylhexyl) phthalate (DEHP) and polychlorinated biphenyls (PCBs) causes reproductive dysfunction in adult male mouse offspring / N. Fiandanese, V Borromeo, A. Berrini, B. Fischer, K. Schaedlich, J.S. Schmidt, C. Secchi, P. Pocar. - In: REPRODUCTIVE TOXICOLOGY. - ISSN 0890-6238. - 65(2016 Oct), pp. 123-132.
|Titolo:||Maternal exposure to a mixture of di(2-ethylhexyl) phthalate (DEHP) and polychlorinated biphenyls (PCBs) causes reproductive dysfunction in adult male mouse offspring|
FIANDANESE, NADIA (Primo)
BORROMEO, VITALIANO (Secondo)
POCAR, PAOLA (Ultimo)
|Parole Chiave:||di(2-ethylhexyl) phthalate (DEHP); polychlorinated biphenyls (PCBs); testis; testosterone; mouse; EDs mixture|
|Settore Scientifico Disciplinare:||Settore VET/01 - Anatomia degli Animali Domestici|
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
|Progetto:||Reproductive effects of environmental chemicals in females|
|Data di pubblicazione:||ott-2016|
|Data ahead of print / Data di stampa:||11-lug-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.reprotox.2016.07.004|
|Appare nelle tipologie:||01 - Articolo su periodico|
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