Substituted phosphathiahelicenes have been prepared via a straightforward two-step procedure involving the regioselective bromination of a preformed helical scaffold, followed by palladium catalyzed coupling reactions. The new helicenes have been used as ligands in gold(i)-catalyzed [4+2] cyclizations of 1,6-enynes. The resulting dihydro-cyclopenta[b]naphthalene derivative was obtained in excellent yields and with up to 91% ee.
|Titolo:||The synthesis of substituted phosphathiahelicenes : Via regioselective bromination of a preformed helical scaffold : A new approach to modular ligands for enantioselective gold-catalysis|
DOVA, DAVIDE (Secondo)
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||ago-2016|
|Digital Object Identifier (DOI):||10.1039/c6cc04765c|
|Appare nelle tipologie:||01 - Articolo su periodico|