We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a p value of 0.005. In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.
A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection / M. Biasin, M. Sironi, I. Saulle, C. Pontremoli, M. Garziano, R. Cagliani, D. Trabattoni, S. Lo Caputo, F. Vichi, F. Mazzotta, D. Forni, S. Riva, W. Aguilar-Jimenez, S. Cedeño, J. Sanchez, C. Brander, W. Zapata, M.T. Rugeles, M. Clerici. - In: MICROBES AND INFECTION. - ISSN 1286-4579. - (2016 Sep 18). [Epub ahead of print]
Titolo: | A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection |
Autori: | BIASIN, MARA (Primo) CLERICI, MARIO SALVATORE (Ultimo) |
Parole Chiave: | HESN; HIV; TIM-1; polymorphism; resistance to infection |
Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale |
Data di pubblicazione: | 18-set-2016 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.micinf.2016.09.005 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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