The aim of the present study was to assess age-dependent changes of proteins in the vastus lateralis muscle of physically active elderly and young subjects by a combination of two-dimensional difference gel electrophoresis, SDS-PAGE and ESI-MS/MS. The differences observed in the elderly group included down-regulation of regulatory myosin light chains, particularly the phosphorylated isoforms, a higher proportion of myosin heavy chain isoforms 1 and 2A, and enhanced oxidative and reduced glycolytic capacity.
The human muscle proteome in aging / C. Gelfi, A. Vigano, M. Ripamonti, A. Pontoglio, S. Begum, M.A. Pellegrino, B. Grassi, R. Bottinelli, R. Wait, P. Cerretelli. - In: JOURNAL OF PROTEOME RESEARCH. - ISSN 1535-3893. - 5:6(2006 Jun), pp. 1344-1353. [10.1021/pr050414x]
The human muscle proteome in aging
C. Gelfi;A. Vigano;B. Grassi;P. Cerretelli
2006
Abstract
The aim of the present study was to assess age-dependent changes of proteins in the vastus lateralis muscle of physically active elderly and young subjects by a combination of two-dimensional difference gel electrophoresis, SDS-PAGE and ESI-MS/MS. The differences observed in the elderly group included down-regulation of regulatory myosin light chains, particularly the phosphorylated isoforms, a higher proportion of myosin heavy chain isoforms 1 and 2A, and enhanced oxidative and reduced glycolytic capacity.
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