OBJECTIVE: Evidence on the long-term impact of controlled ovarian hyperstimulation (COH) on thyroid function is scarce. To investigate this, we report on serum thyroid-stimulating hormone (TSH) modifications in euthyroid and hypothyroid women during COH and 3 months after the end of the stimulation cycle.METHODS: Women who underwent in vitro fertilization (IVF) and who did not become pregnant were eligible. Cases were women with treated hypothyroidism and basal serum TSH <2.5 mIU/L. Controls were euthyroid women matched to cases by age and basal serum TSH. Women could be included if serum TSH was available at 4 time points: prior to initiating COH (time 1); at the time of human chorionic gonadotropin (hCG) administration (time 2); 16 days after hCG administration (time 3); and 3 months after the end of the IVF cycle (time 4).RESULTS: Thirty-seven case-control pairs were included. Serum TSH at times 1, 2, 3, and 4 was 1.7 ± 0.6, 3.1 ± 1.4, 3.1 ± 1.3, and 2.7 ± 1.7 mIU/L, and 1.7 ± 0.6, 2.9 ± 1.0, 2.7 ± 1.0, and 1.9 ± 0.7 mIU/L among cases and controls, respectively. A statistically significant difference emerged at time 4 (P<.001). In both groups, serum TSH was higher at time 4 compared to time 1. Serum TSH exceeded the recommended threshold of 2.5 mIU/L at time 4 in 51% of cases (95% confidence interval [CI], 35 to 68%) and in 16% of controls (95% CI, 4 to 28%) (P = .003).CONCLUSION: COH seems to have a long-term impact on TSH levels. The magnitude of this effect is particularly pronounced in hypothyroid women.
The long-term impact of controlled ovarian hyperstimulation on thyroid function / A. Busnelli, E. Somigliana, S. Ferrari, F. Filippi, G. Vannucchi, L. Fugazzola, L. Fedele. - In: ENDOCRINE PRACTICE. - ISSN 1530-891X. - 22:4(2016 Apr), pp. 389-395.
|Titolo:||The long-term impact of controlled ovarian hyperstimulation on thyroid function|
BUSNELLI, ANDREA (Primo)
SOMIGLIANA, EDGARDO (Secondo)
FUGAZZOLA, LAURA (Penultimo)
FEDELE, LUIGI (Ultimo)
|Parole Chiave:||adult; case-control studies; chorionic gonadotropin; female; fertility agents, female; humans; hypothyroidism; infertility, female; pregnancy; pregnancy complications; retrospective studies; thyroid function tests; thyroid gland; thyrotropin; time factors; ovulation induction; endocrinology, diabetes and metabolism; endocrinology|
|Settore Scientifico Disciplinare:||Settore MED/40 - Ginecologia e Ostetricia|
|Data di pubblicazione:||apr-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.4158/EP15933.OR|
|Appare nelle tipologie:||01 - Articolo su periodico|