Several 17alpha-monoesters of cortexolone and its delta 9-derivative are endowed with antiandrogenic activity. Their synthesis can be accomplished by means of a lipase-catalyzed chemoselective alcoholysis of the corresponding 17alpha,21-diesters.
Lipase-catalyzed preparation of corticosteroid 17alpha-esters endowed with antiandrogenic activity / P. Ferraboschi, M. De Mieri, L. Ragonesi. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 49:31(2008 Jul 28), pp. 4610-4612.
Lipase-catalyzed preparation of corticosteroid 17alpha-esters endowed with antiandrogenic activity
P. FerraboschiPrimo
;M. De MieriSecondo
;
2008
Abstract
Several 17alpha-monoesters of cortexolone and its delta 9-derivative are endowed with antiandrogenic activity. Their synthesis can be accomplished by means of a lipase-catalyzed chemoselective alcoholysis of the corresponding 17alpha,21-diesters.
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