Little and conflicting data are reported in the literature on the efficacy of somatostatin in the treatment of acute bleeding of esophageal varices in patients with portal hypertension due to hepatic cirrhosis. In this study the effectiveness of somatostatin has been evaluated in two groups of patients, one group with profuse and the other group with moderate bleeding (with and without Sengstaken-Blakemore tube). The overall rate of success in the two groups is similar, but the mean bleeding period has been significantly reduced in the somatostatin group (15 patients) in comparison with the cimetidine group (14 patients), both in cases without Sengstaken-Blakemore intubation and in severe cases in which local tamponade was required. Somatostatin also markedly reduced the period of intubation. This study confirms that somatostatin may be used as a safe, first choice therapy in the medical management of acute variceal hemorrhage

Comparison of somatostatin and cimetidine in the treatment of acutely bleeding esophageal varices / P. Testoni, E. Masci, S. Passaretti, A. Malesci, A. Tittobello, U. Comin, E. Ballarin, C. Maggi, R. Arcidiacono. - In: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL. - ISSN 0011-393X. - 39:5(1986 May), pp. 758-767.

Comparison of somatostatin and cimetidine in the treatment of acutely bleeding esophageal varices

A. Malesci;
1986-05

Abstract

Little and conflicting data are reported in the literature on the efficacy of somatostatin in the treatment of acute bleeding of esophageal varices in patients with portal hypertension due to hepatic cirrhosis. In this study the effectiveness of somatostatin has been evaluated in two groups of patients, one group with profuse and the other group with moderate bleeding (with and without Sengstaken-Blakemore tube). The overall rate of success in the two groups is similar, but the mean bleeding period has been significantly reduced in the somatostatin group (15 patients) in comparison with the cimetidine group (14 patients), both in cases without Sengstaken-Blakemore intubation and in severe cases in which local tamponade was required. Somatostatin also markedly reduced the period of intubation. This study confirms that somatostatin may be used as a safe, first choice therapy in the medical management of acute variceal hemorrhage
Settore MED/09 - Medicina Interna
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/434570
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 24
  • ???jsp.display-item.citation.isi??? 18
social impact