Gd-DO3A-diph and Gd-AAZTAC17 are lipophilic magnetic resonance imaging (MRI) agents that display hight affinity for low density lipoprotein (LDL) particles. Their LDL adducts are taken up by human hepatoblastoma G2 (HepG2) and melanoma B16 tumor cells when added to the incubation media. Gd-AAZTAC17/LDL adduct proved to be an efficient probe in the magnetic resonance visualization of subcutaneous tumors in animal models
Magnetic resonance imaging detection of tumor cells by targeting low-density lipoprotein receptors with Gd-loaded low-density lipoprotein particles / S.G. Crich, S. Lanzardo, D. Alberti, S. Belfiore, A. Ciampa, G.B. Giovenzana, C. Lovazzano, R. Pagliarin, S. Aime. - In: NEOPLASIA. - ISSN 1522-8002. - 9:12(2007), pp. 1046-1056.
Magnetic resonance imaging detection of tumor cells by targeting low-density lipoprotein receptors with Gd-loaded low-density lipoprotein particles
R. PagliarinPenultimo
;
2007
Abstract
Gd-DO3A-diph and Gd-AAZTAC17 are lipophilic magnetic resonance imaging (MRI) agents that display hight affinity for low density lipoprotein (LDL) particles. Their LDL adducts are taken up by human hepatoblastoma G2 (HepG2) and melanoma B16 tumor cells when added to the incubation media. Gd-AAZTAC17/LDL adduct proved to be an efficient probe in the magnetic resonance visualization of subcutaneous tumors in animal models
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