Nucleophosmin (NPM) is frequently mutated in acute myeloid leukemias and is thought to act as both a proto-oncogene and a tumor suppressor. Although genetic and molecular evidence has shed light on the mechanisms of NPM-mediated tumor suppression, the potential role of NPM mutants as oncogenes remains ill defined. Now, new data provide a straightforward mechanism for this latter function, as NPM is shown to regulate the stability and the function of MYC. Remarkably, the same leitmotif of "placing a critical cell regulator in the wrong place at the wrong time" appears to underscore all the cancer-promoting activities of mutated NPM.
|Titolo:||Playing both sides : nucleophosmin between tumor suppression and oncogenesis|
|Autori interni:||DI FIORE, PIER PAOLO (Primo)|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||14-lug-2008|
|Digital Object Identifier (DOI):||10.1083/jcb.200806069|
|Appare nelle tipologie:||01 - Articolo su periodico|