The Delta 32-CCR5 deletion of the CCR5 receptor is protective toward coronary artery pathology and myocardial infarction. Maraviroc (MVC), a CCR5 antagonist, was recently introduced in the therapy of HIV infection; we evaluated whether this drug could modulate the atherosclerotic burden in aviremic PI-treated HIV-positive individuals who underwent MVC intensification. Thus, the effect of MVC on intima media thickness, arterial stiffness, metabolic parameters, pro-inflammatory cytokines, endothelial dysfunction, and microbial traslocation markers was analyzed in 6 aviremic PI-treated HIV-positive individuals and were compared to those obtained in 9 additional aviremic PI-treated subjects that were enrolled retrospectively from our outpatients cohort. MVC intensification resulted in a significant reduction in intima media thickness, pulse wave velocity and triglycerides compared to baseline. Notably, MVC was also associated with a significant reduction of IL-6, microbial translocation indexes, sICAM and sVCAM; these changes were maintained throughout the 6 months of MVC intensification. No significant modifications were observed in CD4 counts, HIV viral load, and cholesterolemia. Results herein support a role of CCR5 antagonists in reducing the cardiovascular risk in HIV-infection. The hampering of inflammation, microbial translocation and the improvement of endothelial function could justify the protective role of CCR5 antagonists on atherosclerotic burden.
Maraviroc reduces arterial stiffness in PI-treated HIV-infected patients / S. Piconi, D. Pocaterra, V. Rainone, M. Cossu, M. Masetti, G. Rizzardini, M. Clerici, D. Trabattoni. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 6(2016 Jun 29), pp. 28853.1-28853.5.
|Titolo:||Maraviroc reduces arterial stiffness in PI-treated HIV-infected patients|
PICONI, STEFANIA (Primo)
CLERICI, MARIO SALVATORE (Penultimo)
TRABATTONI, DARIA LUCIA (Corresponding)
|Parole Chiave:||microbial translocation; risk; intensification; individuals; association; trial|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||29-giu-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/srep28853|
|Appare nelle tipologie:||01 - Articolo su periodico|