At present, hypersensitivity and immunosuppression are considered the primary focus for developing in vitro methods in immunotoxicology. Nevertheless, in vitro assays to detect immunostimulation and autoimmunity are also needed. Although developmental immunotoxicity is an emerging concern, there are no in vitro test models available at this time. The purpose of this presentation is to reviewthe stateof- the-art in the field of in vitro immunotoxicity and, in particular, to present data obtained within an ECVAM sponsored project aimed at the optimization of in vitro tests to assess the immunosuppressive potential of chemicals.
|Titolo:||In vitro approaches to the assessment of immunotoxicity|
CORSINI, EMANUELA (Primo)
|Parole Chiave:||cytokine release ; stimulation of lymphocyte proliferation|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||2007|
|Digital Object Identifier (DOI):||10.1016/j.toxlet.2007.05.039|
|Appare nelle tipologie:||01 - Articolo su periodico|