Gonads are very peculiar organs given their bipotential competence. Indeed, early differentiating genital ridges evolve into either of 2 very distinct organs: the testis or the ovary. Accumulating evidence now demonstrates that both genetic pathways must repress the other in order for the organs to differentiate properly, meaning that if this repression is disrupted or attenuated, the other pathway may completely or partially be expressed, leading to disorders of sex development. Among these disorders are the cases of XY male-to-female and XX female-to-male sex reversals as well as true hermaphrodites, in which there is a discrepancy between the chromosomal and gonadal sex. Here, we review known cases of XY and XX sex reversals described in mammals, focusing mostly on domestic animals where sex reversal pathologies occur and on wild species in which deviations from the usual XX/XY system have been documented.
Sex reversal in non-human placental mammals / P. Parma, F. Veyrunes, E. Pailhoux. - In: SEXUAL DEVELOPMENT. - ISSN 1661-5425. - 10:5-6(2016 Dec), pp. 326-344.
Titolo: | Sex reversal in non-human placental mammals | |
Autori: | PARMA, PIETRO (Primo) | |
Parole Chiave: | gonad differentiation; placental mammals; sex determination; sex reversal | |
Settore Scientifico Disciplinare: | Settore AGR/17 - Zootecnica Generale e Miglioramento Genetico | |
Data di pubblicazione: | dic-2016 | |
Rivista: | ||
Tipologia: | Article (author) | |
Data ahead of print / Data di stampa: | 17-ago-2016 | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1159/000448361 | |
Appare nelle tipologie: | 01 - Articolo su periodico |
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Sex-Reversal in mammals - Revised final version.pdf | Post-print, accepted manuscript ecc. (versione accettata dall'editore) | Open Access Visualizza/Apri |