Epidemiological studies strongly suggest a link between stress, depression, and cardiovascular diseases (CVDs); the mechanistic correlation, however, is poorly understood. A single-nucleotide polymorphism in the BDNF gene (BDNFVal66Met), associated with depression and anxiety, has been proposed as a genetic risk factor for CVD. Using a knock-in mouse carrying the BDNFVal66Met human polymorphism, which phenocopies psychiatric-related symptoms found in humans, we investigated the impact of this SNP on thrombosis.
BDNFVal66met polymorphism : a potential bridge between depression and thrombosis / P. Amadio, G.I. Colombo, E. Tarantino, S. Gianellini, A. Ieraci, M. Brioschi, C. Banfi, J.P. Werba, A. Parolari, F.S. Lee, E. Tremoli, S.S. Barbieri. - In: EUROPEAN HEART JOURNAL. - ISSN 0195-668X. - 38:18(2017 May 01), pp. 1426-1435.
Titolo: | BDNFVal66met polymorphism : a potential bridge between depression and thrombosis | |
Autori: | AMADIO, PATRIZIA (Primo) COLOMBO, GUALTIERO (Secondo) TREMOLI, ELENA (Penultimo) BARBIERI, SILVIA STELLA (Ultimo) | |
Parole Chiave: | BDNFVal66Met polymorphism; depression; platelet; thrombosis; vascular inflammation | |
Settore Scientifico Disciplinare: | Settore MED/23 - Chirurgia Cardiaca Settore BIO/14 - Farmacologia Settore BIO/13 - Biologia Applicata Settore BIO/11 - Biologia Molecolare | |
Data di pubblicazione: | 1-mag-2017 | |
Rivista: | ||
Tipologia: | Article (author) | |
Data ahead of print / Data di stampa: | 24-dic-2015 | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1093/eurheartj/ehv655 | |
Appare nelle tipologie: | 01 - Articolo su periodico |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
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2016 EHJ polim BDNFVal.pdf | Publisher's version/PDF | Open Access Visualizza/Apri |