Epidemiological studies strongly suggest a link between stress, depression, and cardiovascular diseases (CVDs); the mechanistic correlation, however, is poorly understood. A single-nucleotide polymorphism in the BDNF gene (BDNFVal66Met), associated with depression and anxiety, has been proposed as a genetic risk factor for CVD. Using a knock-in mouse carrying the BDNFVal66Met human polymorphism, which phenocopies psychiatric-related symptoms found in humans, we investigated the impact of this SNP on thrombosis.
BDNFVal66met polymorphism : a potential bridge between depression and thrombosis / P. Amadio, G.I. Colombo, E. Tarantino, S. Gianellini, A. Ieraci, M. Brioschi, C. Banfi, J.P. Werba, A. Parolari, F.S. Lee, E. Tremoli, S.S. Barbieri. - In: EUROPEAN HEART JOURNAL. - ISSN 0195-668X. - 38:18(2017 May 01), pp. 1426-1435. [10.1093/eurheartj/ehv655]
BDNFVal66met polymorphism : a potential bridge between depression and thrombosis
P. AmadioPrimo
;G.I. ColomboSecondo
;E. Tarantino;S. Gianellini;A. Ieraci;M. Brioschi;C. Banfi;A. Parolari;E. TremoliPenultimo
;S.S. BarbieriUltimo
2017
Abstract
Epidemiological studies strongly suggest a link between stress, depression, and cardiovascular diseases (CVDs); the mechanistic correlation, however, is poorly understood. A single-nucleotide polymorphism in the BDNF gene (BDNFVal66Met), associated with depression and anxiety, has been proposed as a genetic risk factor for CVD. Using a knock-in mouse carrying the BDNFVal66Met human polymorphism, which phenocopies psychiatric-related symptoms found in humans, we investigated the impact of this SNP on thrombosis.
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2016 EHJ polim BDNFVal.pdf
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