Previous studies have demonstrated that the concentration of α1-acid glycoprotein (AGP) transiently increases in asymptomatic cats infected with feline coronavirus (FCoV). In order to establish whether these fluctuations depend on the FCoV status, the serum concentration of AGP and anti-FCoV antibody titres and/or faecal shedding of FCoVs in clinically healthy cats from catteries with different levels of prevalence of FCoV infection were monitored over time. Serum AGP concentrations fluctuated over time in clinically healthy cats from the cattery with the highest prevalence of feline infectious peritonitis (FIP) and significantly increased just before an outbreak of FIP. Further studies are required to clarify whether the observed increase of AGP concentration is a consequence of the increased viral burden or a protective response against mutated viral strains. Nevertheless, the results of the present study suggest that AGP might be useful in monitoring FCoV-host interactions in FCoV-endemic catteries.

Serum alpha1-acid glycoprotein (AGP) concentration in non-symptomatic cats with feline coronavirus (FCoV) infection / S. Paltrinieri, C. Metzger, M. Battilani, V. Pocacqua, M.E. Gelain, A. Giordano. - In: JOURNAL OF FELINE MEDICINE AND SURGERY. - ISSN 1098-612X. - 9:4(2007 Aug), pp. 271-277. [10.1016/j.jfms.2007.01.002]

Serum alpha1-acid glycoprotein (AGP) concentration in non-symptomatic cats with feline coronavirus (FCoV) infection

S. Paltrinieri
Primo
;
V. Pocacqua;M.E. Gelain
Penultimo
;
A. Giordano
Ultimo
2007

Abstract

Previous studies have demonstrated that the concentration of α1-acid glycoprotein (AGP) transiently increases in asymptomatic cats infected with feline coronavirus (FCoV). In order to establish whether these fluctuations depend on the FCoV status, the serum concentration of AGP and anti-FCoV antibody titres and/or faecal shedding of FCoVs in clinically healthy cats from catteries with different levels of prevalence of FCoV infection were monitored over time. Serum AGP concentrations fluctuated over time in clinically healthy cats from the cattery with the highest prevalence of feline infectious peritonitis (FIP) and significantly increased just before an outbreak of FIP. Further studies are required to clarify whether the observed increase of AGP concentration is a consequence of the increased viral burden or a protective response against mutated viral strains. Nevertheless, the results of the present study suggest that AGP might be useful in monitoring FCoV-host interactions in FCoV-endemic catteries.
Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria
ago-2007
Article (author)
File in questo prodotto:
File Dimensione Formato  
j.jfms.2007.01.002.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 156.09 kB
Formato Adobe PDF
156.09 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/42762
Citazioni
  • ???jsp.display-item.citation.pmc??? 17
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 28
social impact