Glycodendrimers based on aromatic cores have an amphiphilic character and have been reported to generate supramolecuar assemblies in water. A new group of glycodendrimers with an aromatic rod-like core were recently described as potent antagonists of DC-SIGN-mediated viral infections. A full characterization of the aggregation properties of these materials is presented here. The results show that these compounds exist mostly as monomers in water solution, in dynamic equilibrium with small aggregates (dimers or trimers). Larger aggregates observed by dynamic light scattering and transmission Electron Microscopy for some of the dendrimers are found to be portions of materials not fully solubilized and can be removed either by optimizing the dissolution protocol or by centrifugation of the samples. (Figure presented.) .
Solution Behavior of Amphiphilic Glycodendrimers with a Rod-Like Core / S. Ordanini, G. Zanchetta, V. Porkolab, C. Ebel, F. Fieschi, I. Guzzetti, D. Potenza, A. Palmioli, Č. Podlipnik, D. Meroni, A. Bernardi. - In: MACROMOLECULAR BIOSCIENCE. - ISSN 1616-5187. - 16:6(2016 Jun), pp. 896-905.
|Titolo:||Solution Behavior of Amphiphilic Glycodendrimers with a Rod-Like Core|
ORDANINI, STEFANIA (Primo)
ZANCHETTA, GIULIANO (Secondo)
MERONI, DANIELA (Penultimo)
BERNARDI, ANNA (Corresponding)
|Parole Chiave:||DC-SIGN; glycodendrimers; glycomimetics; HIV; morphological characterization; Biotechnology; Bioengineering; Biomaterials; Polymers and Plastics; Materials Chemistry2506 Metals and Alloys|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||giu-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/mabi.201500452|
|Appare nelle tipologie:||01 - Articolo su periodico|