A few naturally occurring N6-substituted adenosine derivatives (cytokinin ribosides) were investigated as inhibitors of platelet aggregation induced in vitro by collagen and their activity range was demonstrated (IC50: 6.77-141 μM). A docking study suggests that anti-aggregation activity of these compounds could involve an interaction with the P2Y12 receptor binding site.
Naturally occurring N6-substituted adenosines (cytokinin ribosides) are in vitro inhibitors of platelet aggregation : An in silico evaluation of their interaction with the P2Y12 receptor / G. Vistoli, A. Brizzolari, E. Faioni, C. Razzari, E. Santaniello. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 24:24(2014 Dec 15), pp. 5652-5655.
|Titolo:||Naturally occurring N6-substituted adenosines (cytokinin ribosides) are in vitro inhibitors of platelet aggregation : An in silico evaluation of their interaction with the P2Y12 receptor|
VISTOLI, GIULIO (Corresponding)
BRIZZOLARI, ANDREA (Secondo)
RAZZARI, CRISTINA (Penultimo)
SANTANIELLO, ENZO (Ultimo)
|Parole Chiave:||Anti-aggregation activity; Cytokinin ribosides; Homology modeling; Molecular docking; P2Y12 receptor; Platelets; Adenosine; Adenosine Diphosphate; Blood Platelets; Cytokinins; Humans; In Vitro Techniques; Plant Growth Regulators; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Receptors, Purinergic P2Y12; Ribonucleosides; Biochemistry; Clinical Biochemistry; Molecular Biology; Molecular Medicine; Organic Chemistry; Drug Discovery3003 Pharmaceutical Science; 3003; Medicine (all)|
|Settore Scientifico Disciplinare:||Settore CHIM/08 - Chimica Farmaceutica|
|Data di pubblicazione:||15-dic-2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.bmcl.2014.10.080|
|Appare nelle tipologie:||01 - Articolo su periodico|