A few naturally occurring N6-substituted adenosine derivatives (cytokinin ribosides) were investigated as inhibitors of platelet aggregation induced in vitro by collagen and their activity range was demonstrated (IC50: 6.77-141 μM). A docking study suggests that anti-aggregation activity of these compounds could involve an interaction with the P2Y12 receptor binding site.
Naturally occurring N6-substituted adenosines (cytokinin ribosides) are in vitro inhibitors of platelet aggregation : An in silico evaluation of their interaction with the P2Y12 receptor / G. Vistoli, A. Brizzolari, E. Faioni, C. Razzari, E. Santaniello. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 24:24(2014 Dec 15), pp. 5652-5655. [10.1016/j.bmcl.2014.10.080]
Naturally occurring N6-substituted adenosines (cytokinin ribosides) are in vitro inhibitors of platelet aggregation : An in silico evaluation of their interaction with the P2Y12 receptor
G. Vistoli
;A. BrizzolariSecondo
;E. Faioni;C. RazzariPenultimo
;E. SantanielloUltimo
2014
Abstract
A few naturally occurring N6-substituted adenosine derivatives (cytokinin ribosides) were investigated as inhibitors of platelet aggregation induced in vitro by collagen and their activity range was demonstrated (IC50: 6.77-141 μM). A docking study suggests that anti-aggregation activity of these compounds could involve an interaction with the P2Y12 receptor binding site.
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