The aim of this study was to investigate the origin and geographical dispersion of Marburg virus, the first member of the Filoviridae family to be discovered. Seventy-three complete genome sequences of Marburg virus isolated from animals and humans were retrieved from public databases and analysed using a Bayesian phylogeographical framework. The phylogenetic tree of the Marburg virus data set showed two significant evolutionary lineages: Ravn virus (RAVV) and Marburg virus (MARV). MARV divided into two main clades; clade A included isolates from Uganda (five from the European epidemic in 1967), Kenya (1980) and Angola (from the epidemic of 2004-2005); clade B included most of the isolates obtained during the 1999-2000 epidemic in the Democratic Republic of the Congo (DRC) and a group of Ugandan isolates obtained in 2007-2009. The estimated mean evolutionary rate of the whole genome was 3.3 × 10-4 substitutions/site/year (credibility interval 2.0-4.8). The MARV strain had a mean root time of the most recent common ancestor of 177.9 years ago (YA) (95% highest posterior density 87-284), thus indicating that it probably originated in the mid-XIX century, whereas the RAVV strain had a later origin dating back to a mean 33.8 YA. The most probable location of the MARV ancestor was Uganda (state posterior probability, spp = 0.41), whereas that of the RAVV ancestor was Kenya (spp = 0.71). There were significant migration rates from Uganda to the DRC (Bayes Factor, BF = 42.0) and in the opposite direction (BF = 5.7). Our data suggest that Uganda may have been the cradle of Marburg virus in Africa.
Distribution of Marburg virus in Africa: An evolutionary approach / G. Zehender, C. Sorrentino, C. Veo, L. Fiaschi, S. Gioffrè, E. Ebranati, E. Tanzi, M. Ciccozzi, A. Lai, M. Galli. - In: INFECTION GENETICS AND EVOLUTION. - ISSN 1567-1348. - 44(2016 Oct), pp. 8-16.
|Titolo:||Distribution of Marburg virus in Africa: An evolutionary approach|
ZEHENDER, GIANGUGLIELMO (Corresponding)
SORRENTINO, CHIARA (Secondo)
LAI, ALESSIA (Penultimo)
GALLI, MASSIMO (Ultimo)
|Parole Chiave:||Marburg virus; Ravn virus; Geographic dispersion; Phylodynamics|
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale e Applicata|
Settore MED/17 - Malattie Infettive
Settore MED/07 - Microbiologia e Microbiologia Clinica
|Data di pubblicazione:||ott-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.meegid.2016.06.014|
|Appare nelle tipologie:||01 - Articolo su periodico|