Objective: The aim of the study was to retrospectively investigate the association between initial oxygen concentration in delivery room and short-term outcomes in preterm infants.Methods: Data from infants needing neonatal resuscitation, born at our department between January 2008 and December 2011, were analyzed. Patients were divided into three groups based on gestational age: between 32 and 36 weeks, between 31 and 28 weeks, and below 28 weeks.Results: The administration of each additional unit of oxygen up to 50% showed an association with a 5% increased need for mechanical ventilation (MV) in the neonatal intensive care unit in infants between 32 and 36 weeks [adjusted odds ratio 1.1, 95% confidence interval (CI) 1.04-1.1] and infants between 28 and 31 weeks (adjusted odds ratio 1.12, 95% CI 1.08-1.44). On the contrary, in infants below 28 weeks, increasing initial concentration of supplementary oxygen did not show any association with MV.Conclusions: Initial oxygen concentration seems to be associated with increased MV in the NICU. Our observations further stress the need for randomized controlled studies in order to obtain definitive recommendations for the optimal initial oxygen concentration during neonatal resuscitation of preterm infants.
Oxygen administration at birth in preterm infants : A retrospective analysis / M. Pierro, F. Ciralli, M. Colnaghi, M. Vanzati, D. Mercadante, D. Consonni, F. Mosca. - In: THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. - ISSN 1476-7058. - 29:16(2016 Aug 17), pp. 2675-2680.
|Titolo:||Oxygen administration at birth in preterm infants : A retrospective analysis|
PIERRO, MARIA (Corresponding)
MOSCA, FABIO (Ultimo)
|Parole Chiave:||guidelines; mechanical ventilation; neonatal resuscitation; oxygen; preterm; pediatrics, perinatology and child health; obstetrics and gynecology|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Data di pubblicazione:||17-ago-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3109/14767058.2015.1100161|
|Appare nelle tipologie:||01 - Articolo su periodico|