The incidence of cancer increases with age but we do not know why. As a working hypothesis we propose here that cells somehow initiated in vivo in the course of life and finally engaged in the aging program, which involves a drop of connexins with loss of cell-to-cell communication (equivalent to the promotion phase in the multistep process of carcinogenesis), may recover their growth potential, thus allowing cancer to progress. This is supported by evidence that: (i) connexin 43 (Cx43) acts as a tumor suppressor; (ii) cx43 and gap junction intercellular communication drop in precancerous lesions and in tumors of various origins, as well as in aging cells; (iii) telomerase is activated in cancerous somatic cells.
|Titolo:||Drop of connexins : a possible link between aging and cancer?|
DEL MONTE, UGO (Primo)
|Parole Chiave:||Aging; Cancer; Connexin 43; Gap junction; Intercellular communication; Replicative senescence|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||feb-2004|
|Digital Object Identifier (DOI):||10.1016/j.exger.2003.10.010|
|Appare nelle tipologie:||01 - Articolo su periodico|