OBJECTIVE: Endocrine pathways seem to play a role in the etiology of major psychoses. The identification of biomarkers associated with psychotic symptoms in schizophrenia (SKZ) and mood disorders would allow the identification of high-risk subjects for delusions and hallucinations. The aim of this study was to evaluate dehydroepiandrosterone sulfate (DHEA-S) and progesterone plasma levels in drug-free patients with major psychoses and their relation with the diagnosis and history of psychotic symptoms. METHODS: Eighty-nine consecutive drug-free male inpatients with SKZ or mood disorders were recruited, and DHEA-S and progesterone plasma levels were measured. The groups, divided according to pathological/normal-range hormone levels, were compared in terms of clinical variables using x03C7;2 tests with Bonferroni's corrections or multivariate analyses of variance. The same analyses were performed for groups divided according to the presence/absence of lifetime psychotic symptoms. Binary logistic regression analysis was performed using hormone levels as independent variables and history of lifetime psychotic symptoms as a dependent one. RESULTS: A higher number of patients with abnormal DHEA-S levels was found to have a family history of major depressive disorder (p < 0.05). Higher DHEA-S levels (F = 8.31; p = 0.005) were found in patients with a history of psychotic symptoms. In addition, binary logistic regression confirmed that DHEA-S levels were associated with a higher probability of lifetime psychotic symptoms (p = 0.037). CONCLUSIONS: Our results confirm previous data about the role of endocrine factors in the etiology of major psychoses. A high DHEA-S level might be a risk factor for psychotic symptoms. Studies with larger samples are needed to confirm these data.
Sex Steroids and Major Psychoses : which Role for DHEA-S and Progesterone / M. Buoli, A. Caldiroli, M. Serati, S. Grassi, A. Altamura. - In: NEUROPSYCHOBIOLOGY. - ISSN 0302-282X. - 73:3(2016), pp. 178-183.
|Titolo:||Sex Steroids and Major Psychoses : which Role for DHEA-S and Progesterone|
BUOLI, MASSIMILIANO (Primo)
CALDIROLI, ALICE (Secondo)
GRASSI, SILVIA (Penultimo)
ALTAMURA, ALFREDO CARLO (Ultimo)
|Parole Chiave:||dehydroepiandrosterone sulfate; major psychoses; neuroendocrine biomarkers; progesterone|
|Settore Scientifico Disciplinare:||Settore MED/25 - Psichiatria|
|Data di pubblicazione:||2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000444922|
|Appare nelle tipologie:||01 - Articolo su periodico|