New clean and efficient methods for the production of 2-methyl-1,4-naphthoquinone (MNQ, menadione, Vitamin K3) based on the oxidation of 2-methyl-1-naphthol (MNL) with cheap and environmentally benign oxidants, aqueous hydrogen peroxide, tert-butyl hydroperoxide and molecular oxygen, using three types of true heterogeneous catalysts, such as hydrothermally stable mesoporous titanium-silicate Ti-MMM-2, silica supported iron phthalocyanine and supported gold nanoparticles, are reported. Advantages and drawbacks of the catalytic systems are discussed. Surprisingly, non-catalytic oxidation of MNL with molecular oxygen shows superior selectivity and volume yield of MNQ compared to the known catalytic methods.

New routes to vitamin K3 / O.A. Kholdeeva, O.V. Zalomaeva, A.B. Sorokin, I.D. Ivanchikova, C. Della Pina, M. Rossi. - In: CATALYSIS TODAY. - ISSN 0920-5861. - 121:1/2(2007), pp. 58-64.

New routes to vitamin K3

C. Della Pina
Penultimo
;
M. Rossi
Ultimo
2007

Abstract

New clean and efficient methods for the production of 2-methyl-1,4-naphthoquinone (MNQ, menadione, Vitamin K3) based on the oxidation of 2-methyl-1-naphthol (MNL) with cheap and environmentally benign oxidants, aqueous hydrogen peroxide, tert-butyl hydroperoxide and molecular oxygen, using three types of true heterogeneous catalysts, such as hydrothermally stable mesoporous titanium-silicate Ti-MMM-2, silica supported iron phthalocyanine and supported gold nanoparticles, are reported. Advantages and drawbacks of the catalytic systems are discussed. Surprisingly, non-catalytic oxidation of MNL with molecular oxygen shows superior selectivity and volume yield of MNQ compared to the known catalytic methods.
2-Methyl-1,4-naphthoquinone; 2-Methyl-1-naphthol; H2O2; Menadione; Molecular oxygen; Tert-butyl hydroperoxide
Settore CHIM/03 - Chimica Generale e Inorganica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/42205
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