Background: Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied. Patients and Methods: Genotypes of several variants in both COX1 (Ex7+31 C>A and Ex10-4 G>A) and COX2 (-765 G>C, Ex10+837 T>C, Ex10-90 C>T, IVS5-275 T>G, and IVS7+111 T>C) were identified by TaqMan™ assays in 305 gastric cancer cases and 427 age- and gender-matched controls in a high-risk Polish population. Odds ratios for gastric cancer and 95% confidence intervals from unconditional logistic regression models were used to evaluate relative risks. Results: We found no statistically significant evidence that the polymorphisms tested in COX1 and COX2 are associated with gastric cancer risk. Conclusion: These results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer.
COX1 and COX2 polymorphisms and gastric cancer risk in a Polish population / L. Hou, P. Grillo, Z.Z. Zhu, J. Lissowska, M. Yeager, W. Zatonski, G. Zhu, A. Baccarelli, S.J. Chanock, J.F. Fraumeni, W.H. Chow. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 27:6C(2007), pp. 4243-4247.
COX1 and COX2 polymorphisms and gastric cancer risk in a Polish population
A. Baccarelli;
2007
Abstract
Background: Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied. Patients and Methods: Genotypes of several variants in both COX1 (Ex7+31 C>A and Ex10-4 G>A) and COX2 (-765 G>C, Ex10+837 T>C, Ex10-90 C>T, IVS5-275 T>G, and IVS7+111 T>C) were identified by TaqMan™ assays in 305 gastric cancer cases and 427 age- and gender-matched controls in a high-risk Polish population. Odds ratios for gastric cancer and 95% confidence intervals from unconditional logistic regression models were used to evaluate relative risks. Results: We found no statistically significant evidence that the polymorphisms tested in COX1 and COX2 are associated with gastric cancer risk. Conclusion: These results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer.
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