Purpose Temperature plays a fundamental role for the proper functioning of the brain. However, there are only fragmentary data on brain temperature (Tbr) and its regulation under different physiological conditions. Methods We studied Tbr in the visual cortex of 20 normal subjects serially with a wide temporal window under different states including rest, activation and recovery by a visual stimulation- Magnetic Resonance Spectroscopy Thermometry combined approach.We also studied Tbr in a control region, the centrum semiovale, under the same conditions. Results Visual cortex mean baseline Tbr was higher than mean body temperature (37.38 vs 36.60, P<0.001). During activation Tbr remained unchanged at first and then showed a small decrease (-0.20 CA°) around the baseline value. After the end of activation Tbr increased consistently (+0.60 CA°) and then returned to baseline values after some minutes. Centrum semiovale Tbr remained unchanged through rest, visual stimulation and recovery. Conclusion These findings have several implications, among them that neuronal firing itself is not a major source of heat release in the brain and that there is an aftermath of brain activation that lasts minutes before returning to baseline conditions.

Post-activation brain warming: A 1-H MRS thermometry study / M. Rango, C. Bonifati, N. Bresolin. - In: PLOS ONE. - ISSN 1932-6203. - 10:5(2015 May 26), pp. e0127314.1-e0127314.12.

Post-activation brain warming: A 1-H MRS thermometry study

M. Rango;N. Bresolin
Ultimo
2015

Abstract

Purpose Temperature plays a fundamental role for the proper functioning of the brain. However, there are only fragmentary data on brain temperature (Tbr) and its regulation under different physiological conditions. Methods We studied Tbr in the visual cortex of 20 normal subjects serially with a wide temporal window under different states including rest, activation and recovery by a visual stimulation- Magnetic Resonance Spectroscopy Thermometry combined approach.We also studied Tbr in a control region, the centrum semiovale, under the same conditions. Results Visual cortex mean baseline Tbr was higher than mean body temperature (37.38 vs 36.60, P<0.001). During activation Tbr remained unchanged at first and then showed a small decrease (-0.20 CA°) around the baseline value. After the end of activation Tbr increased consistently (+0.60 CA°) and then returned to baseline values after some minutes. Centrum semiovale Tbr remained unchanged through rest, visual stimulation and recovery. Conclusion These findings have several implications, among them that neuronal firing itself is not a major source of heat release in the brain and that there is an aftermath of brain activation that lasts minutes before returning to baseline conditions.
Adult; Body Temperature; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Photic Stimulation; Thermometry; Visual Cortex; Agricultural and Biological Sciences (all); Biochemistry, Genetics and Molecular Biology (all); Medicine (all)
Settore MED/26 - Neurologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/420780
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