An acquired JAK2V617F mutation has been found in myeloid cells from most patients with chronic idiopathic myelofibrosis (IM), but whether it occurs in a common myelo-lymphoid, rather than a myeloid-restricted, progenitor cell is still debated. Using a sensitive ARMS assay for the quantitative assessment of JAK2V617F cDNA, we detected the mutation in purified B, T and NK cells from about half of 12 patients studied. These results indicate that involvement of the lymphoid lineage in IM may be more frequent than previously supposed.
|Titolo:||Molecular targeting of the PKC-beta inhibitor enzastaurin (LY317615) in multiple myeloma|
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
|Data di pubblicazione:||2007|
|Digital Object Identifier (DOI):||10.3324/haematol.10527|
|Appare nelle tipologie:||01 - Articolo su periodico|