Background and Aim: Autologous platelet-rich fibrin (PRF) and barrier membranes in the treatment of intrabony defects in chronic periodontitis patients have shown significant clinical benefits. This study evaluates the additive effect of autologous PRF in combination with a barrier membrane versus the use of barrier membrane alone for the treatment of intrabony defects in chronic periodontitis patients. Methods: Arandomized split-mouth designwas used. Sixteen patients with 32 paired intrabony defects were included. In each patient 1 defect was treated using a resorbable collagen membrane along with PRF (test group) and the other defect by guided tissue regeneration alone (control group). The following clinical parameters were measured at baseline and after 9 months: plaque index, modified sulcus bleeding index, probing pocket depth, clinical attachment level, and gingival marginal level. The radiographic defect depth was also assessed at baseline and after 9 months. Results: Test group showed a statistically significant improvement for probing depth (P=0.002), clinical attachment level (P=0.001), and radiographic defect depth (P<0.001) after 9 months as compared with the control sites. Radiographic defect depth reduction was 58.19±13.24% in the test group as compared with 24.86±9.94% reduction in the control group. Conclusions: The adjunctive use of PRF in combination with barrier membrane is more effective in the treatment of intrabony defects in chronic periodontitis as compared with barrier membrane alone.

Adjunctive effect of autologus platelet-rich fibrin to barrier membrane in the treatment of periodontal intrabony defects / S. Panda, M. Sankari, A. Satpathy, D. Jayakumar, M. Mozzati, C. Mortellaro, G. Gallesio, S. Taschieri, M. Del Fabbro. - In: THE JOURNAL OF CRANIOFACIAL SURGERY. - ISSN 1049-2275. - 27:3(2016 May), pp. 691-696.

Adjunctive effect of autologus platelet-rich fibrin to barrier membrane in the treatment of periodontal intrabony defects

S. Taschieri;M. Del Fabbro
2016-05

Abstract

Background and Aim: Autologous platelet-rich fibrin (PRF) and barrier membranes in the treatment of intrabony defects in chronic periodontitis patients have shown significant clinical benefits. This study evaluates the additive effect of autologous PRF in combination with a barrier membrane versus the use of barrier membrane alone for the treatment of intrabony defects in chronic periodontitis patients. Methods: Arandomized split-mouth designwas used. Sixteen patients with 32 paired intrabony defects were included. In each patient 1 defect was treated using a resorbable collagen membrane along with PRF (test group) and the other defect by guided tissue regeneration alone (control group). The following clinical parameters were measured at baseline and after 9 months: plaque index, modified sulcus bleeding index, probing pocket depth, clinical attachment level, and gingival marginal level. The radiographic defect depth was also assessed at baseline and after 9 months. Results: Test group showed a statistically significant improvement for probing depth (P=0.002), clinical attachment level (P=0.001), and radiographic defect depth (P<0.001) after 9 months as compared with the control sites. Radiographic defect depth reduction was 58.19±13.24% in the test group as compared with 24.86±9.94% reduction in the control group. Conclusions: The adjunctive use of PRF in combination with barrier membrane is more effective in the treatment of intrabony defects in chronic periodontitis as compared with barrier membrane alone.
Barrier membrane; Guided tissue regeneration; Intrabony defects; Periodontal regeneration; Platelet-rich fibrin; Randomized clinical trial; Otorhinolaryngology2734 Pathology and Forensic Medicine; Surgery
Settore MED/28 - Malattie Odontostomatologiche
THE JOURNAL OF CRANIOFACIAL SURGERY
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/417977
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