This work presents a portable transdermal drug delivery system that combines a magnetically actuated micro gear pump with a microneedle array. Micropart fabrication is performed through DXRL and LIGA techniques. The manufacturing process of both micropump and microneedle array are described together with wear issues. Results show that the assembled device can deliver rates that go from 0.1 to 1.2 ml/min at gear speed ranging from 1000 to 8500 rpm. First skin piercing experiments are also described.

A compact and disposable transdermal drug delivery system / M. Matteucci, M. Casella, M. Bedoni, E. Donetti, M. Fanetti, F. De Angelis, F. Gramatica, E. Di Fabrizio. - In: MICROELECTRONIC ENGINEERING. - ISSN 0167-9317. - 85:5-6(2008), pp. 1066-1073. [10.1016/j.mee.2007.12.067]

A compact and disposable transdermal drug delivery system

M. Bedoni;E. Donetti;
2008

Abstract

This work presents a portable transdermal drug delivery system that combines a magnetically actuated micro gear pump with a microneedle array. Micropart fabrication is performed through DXRL and LIGA techniques. The manufacturing process of both micropump and microneedle array are described together with wear issues. Results show that the assembled device can deliver rates that go from 0.1 to 1.2 ml/min at gear speed ranging from 1000 to 8500 rpm. First skin piercing experiments are also described.
Deep X-ray lithography; LIGA; Soft lithography; Transdermal drug delivery
Settore BIO/16 - Anatomia Umana
2008
Article (author)
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0167931707007885-main.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 3.23 MB
Formato Adobe PDF
3.23 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/41176
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 30
  • ???jsp.display-item.citation.isi??? 23
social impact