Azabicyclo[4.3.0]alkanes appropriately substituted on both cycles have been synthesized as potential scaffold mimics of the RGD signaling motif of integrin. Two sets of functionalized azabicycloalkanes have been examined. In vitro assays established that 21 has a good affinity specifically for αvβ3.
Nonpeptide Integrin Antagonists : RGD Mimetics Incorporating Substituted Azabicycloalkanes as Amino Acid Replacements / L. Manzoni, M. Bassanini, L. Belvisi, I. Motto, C. Scolastico, M. Castorina, C. Pisano. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - :8(2007), pp. 1309-1317. [10.1002/ejoc.200600840]
Nonpeptide Integrin Antagonists : RGD Mimetics Incorporating Substituted Azabicycloalkanes as Amino Acid Replacements
M. BassaniniSecondo
;L. Belvisi;I. Motto;C. Scolastico;
2007
Abstract
Azabicyclo[4.3.0]alkanes appropriately substituted on both cycles have been synthesized as potential scaffold mimics of the RGD signaling motif of integrin. Two sets of functionalized azabicycloalkanes have been examined. In vitro assays established that 21 has a good affinity specifically for αvβ3.
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