It has been suggested that the individual susceptibility to develop agranulocytosis and the patients' responsiveness to clozapine are both Human Leukocyte Antigen (HLA) associated. The study below was designed to re-examine the role of HLA antigens in influencing the clinical outcome of clozapine treatment in schizophrenic patients refractory to treatment. 112 Italian schizophrenic outpatients were treated with clozapine for 8 months. BPRS was used to assess clinical symptomatology at baseline (T0) and after 8 months' clozapine therapy (T1). HLA were serologically typed on peripheral blood lymphocytes at T1. None of the patients developed agranulocytosis or leucopenia. 23 patients (20.53%) were rated as high clozapine responders (as defined by a BPRS score reduced by =60% from T0 to T1) and 46 patients (41.06%) as low clozapine responders (as defined by a BPRS score reduced by <40% from T0 to T1). Looking at the frequencies of HLA antigens between high and low clozapine responders, our results show that HLA B35 seems to be a strong predictor of a high response to the drug (high responders vs low clozapine responders OR = 3.65, p = 0.042). Our results suggest that HLA-B35 antigen behaves like strong and independent predictor of clozapine responsiveness in Italian schizophrenic patients refractory to treatment.
|Titolo:||Markers biologici di risposta clinica alla clozapina in soggetti schizofrenici resistenti al trattamento : il ruolo degli antigeni del sistema HLA|
|Supervisori e coordinatori interni:||GIOVANNINI, MARCELLO|
|Data di pubblicazione:||2005|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
Settore MED/25 - Psichiatria
|Citazione:||Markers biologici di risposta clinica alla clozapina in soggetti schizofrenici resistenti al trattamento : il ruolo degli antigeni del sistema HLA ; M. Giovannini, S. Scarone. - Milano : Università degli studi di Milano. DIPARTIMENTO DI MEDICINA, CHIRURGIA E ODONTOIATRIA, 2005. ((17. ciclo, Anno Accademico 2004/2005.|
|Appare nelle tipologie:||13 - Tesi di dottorato discussa entro ottobre 2010|