Background The lung allocation score (LAS) was introduced in the United States in May 2005 with the main goal of reducing the waiting list mortality of patients with end-stage lung diseases, but also to enhance the lung transplant benefit and improve the management of urgent candidates. Several papers have reported that LAS resulted in a reduction of the waiting list mortality but no significant survival benefit was noted. Methods We evaluate the usefulness of LAS as a predictor for lung transplantation outcome in 123 patients listed for lung transplantation in an Italian center. Primary endpoints were waiting list mortality and posttransplant mortality at 1 year; secondary endpoints included perioperative circulatory support, cardiopulmonary bypass, primary graft dysfunction, and long-term survival after transplantation. Results We observed the absence of correlation between LAS and waiting list mortality. The LAS did not affect the long-term survival in our population. Conclusions High LAS was predictive of primary graft dysfunction of grade 3 in the first 72 hours after transplantation.

Lung Allocation Score : a Single-Center Simulation / L. Rosso, A. Palleschi, D. Tosi, P. Mendogni, I. Righi, R. Carrinola, M. Montoli, F. Damarco, V. Rossetti, L.C. Morlacchi, M. Nosotti. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 48:2(2016 Mar), pp. 391-394. [10.1016/j.transproceed.2015.12.058]

Lung Allocation Score : a Single-Center Simulation

L. Rosso;A. Palleschi;M. Montoli;F. Damarco;M. Nosotti
Ultimo
2016-03

Abstract

Background The lung allocation score (LAS) was introduced in the United States in May 2005 with the main goal of reducing the waiting list mortality of patients with end-stage lung diseases, but also to enhance the lung transplant benefit and improve the management of urgent candidates. Several papers have reported that LAS resulted in a reduction of the waiting list mortality but no significant survival benefit was noted. Methods We evaluate the usefulness of LAS as a predictor for lung transplantation outcome in 123 patients listed for lung transplantation in an Italian center. Primary endpoints were waiting list mortality and posttransplant mortality at 1 year; secondary endpoints included perioperative circulatory support, cardiopulmonary bypass, primary graft dysfunction, and long-term survival after transplantation. Results We observed the absence of correlation between LAS and waiting list mortality. The LAS did not affect the long-term survival in our population. Conclusions High LAS was predictive of primary graft dysfunction of grade 3 in the first 72 hours after transplantation.
Surgery; Transplantation
Settore MED/21 - Chirurgia Toracica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/399737
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