The perception of HAART failure in achieving broadest immune reconstitution has further strengthened the rationale to widely explore new adjuvant immunotherapy. Most work has been performed on IL-2, given its potential to correct HIV-driven immune defects, possibly translating in enhanced immune competency. This is a literature review report reviewing different trials on IL-2 immunotherapy in HIV/AIDS in the past ten years through the Cochrane and NIH review database. IL-2 can benefit severely compromised patients, either HAART-naïve or lacking HAART-driven immune rescue. Furthermore, by sparing HAART-related toxicity, IL-2 is indicated within treatment interruptions or immunization protocols. Important clinical insights stem from the IL-2-mediated immune reconstitution, with a rise in long-term peripheral T-cell turnover, survival and functional markers. Furthermore, IL-2 immunotherapy proved to interfere with cytokine networks with specific regulatory functions over T-cell homeostasis and function. Despite the plethora of immunological findings exploring the intriguing hypothesis that IL-2 might contribute to amend the skewed T-cell immunophenotype and cytokine milieu in HIV/AIDS, major question on the actual clinical impact remain unanswered. This review is meant to thoroughly explore the possibility that the immunological advantages described during IL-2 immunotherapy might translate into actual clinical benefits in the treatment of HIV/AIDS disease.
The challenge of IL-2 Immunotherapy in HIV Disease : “No through Road” or turning point? / G. Marchetti, C. Tincati, A. d'Arminio Monforte, A. Gori. - In: CURRENT HIV RESEARCH. - ISSN 1570-162X. - 6:3(2008), pp. 189-199.
|Titolo:||The challenge of IL-2 Immunotherapy in HIV Disease : “No through Road” or turning point?|
MARCHETTI, GIULIA CARLA (Corresponding)
TINCATI, CAMILLA (Secondo)
D'ARMINIO MONFORTE, ANTONELLA (Penultimo)
|Parole Chiave:||HAART; immune reconstitution; immunotherapy; interleukin-2|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Data di pubblicazione:||2008|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.2174/157016208784325029|
|Appare nelle tipologie:||01 - Articolo su periodico|