Purpose- To evaluate the risk of having a baby with congenital anomalies in mothers who used misoprostol during pregnancy.Methods- Hospital-based case - control study from Hospital Chateaubriand, Fortaleza, Brasil. Cases were 37 babies weighing less than 1500 g with congenital anomalies of various types, and the comparison group included 387 infants also weighing less than 1500 g, and without congenital anomalies.Results- The multivariate odds ratio of having a baby with congenital anomalies was 2.4 (95% confidence interval 1.0 - 6.2) in mothers who reported having used misoprostol compared with those who did not.Conclusions- Misoprostol use during pregnancy might be related to a broad spectrum of congenital anomalies in infants.
Misoprostol and congenital anomalies / R. Brasil, H. Lutéscia Coelho, B. D'Avanzo, C. La Vecchia. - In: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. - ISSN 1053-8569. - 9:5(2000 Oct 20), pp. 401-403.
Misoprostol and congenital anomalies
C. La VecchiaUltimo
2000
Abstract
Purpose- To evaluate the risk of having a baby with congenital anomalies in mothers who used misoprostol during pregnancy.Methods- Hospital-based case - control study from Hospital Chateaubriand, Fortaleza, Brasil. Cases were 37 babies weighing less than 1500 g with congenital anomalies of various types, and the comparison group included 387 infants also weighing less than 1500 g, and without congenital anomalies.Results- The multivariate odds ratio of having a baby with congenital anomalies was 2.4 (95% confidence interval 1.0 - 6.2) in mothers who reported having used misoprostol compared with those who did not.Conclusions- Misoprostol use during pregnancy might be related to a broad spectrum of congenital anomalies in infants.File | Dimensione | Formato | |
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