A major challenge in drug discovery is the definition of the activity of therapeutic compounds before they enter clinical trials. Currently, many tools are available to profile drug response at a multiparametric level. Furthermore, the novel discipline of systems biology is offering interpretative cues to the amount of data generated by the so-called omics technologies. Nonetheless, novel approaches are needed to comprehensively evaluate drug response. This review will describe a recent technology for protein profiling, the ImmunoCell-Array, which, in to the authors' opinion, can enter the scenario of profiling technologies with the goal of offering a comprehensive description of proteome dynamics in a cellular context.

ImmunoCell-Array : a novel technology for pathways discovery and cell profiling / L. Giorgetti, A. Zanardi, S. Venturini, R. Carbone. - In: EXPERT REVIEW OF PROTEOMICS. - ISSN 1478-9450. - 4:5(2007), pp. 609-616.

ImmunoCell-Array : a novel technology for pathways discovery and cell profiling

L. Giorgetti;
2007

Abstract

A major challenge in drug discovery is the definition of the activity of therapeutic compounds before they enter clinical trials. Currently, many tools are available to profile drug response at a multiparametric level. Furthermore, the novel discipline of systems biology is offering interpretative cues to the amount of data generated by the so-called omics technologies. Nonetheless, novel approaches are needed to comprehensively evaluate drug response. This review will describe a recent technology for protein profiling, the ImmunoCell-Array, which, in to the authors' opinion, can enter the scenario of profiling technologies with the goal of offering a comprehensive description of proteome dynamics in a cellular context.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/39609
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