Objectives: An observational study was planned by the QwABIOS group, to survey the hormonal treatment administered to prostate cancer patients in Italy within a time win dow of 12 months. We report here a prospective quality of life (QOL) evaluation over time and by hormonal treatment modalities. Methods: Patients with diagnosis of prostate cancer and treated with hormonal therapy were eligible for thh study. The EORTC QLQ-C30 v.3 questionnaire was administered at enrol ment, after 6 months and after 12 months from enrolment. Results: 587 patients were enrolled by 33 urological centers. When 1518 vuits were considered together independently of time, antiandrogen monotherapy was associated with a significantly bet ter QOL than LHRH-analogue containing treatment modalities in almost all functional scales; cyproterone acetate demonstrated a better physical function and general health status than bica lutamide. When QOL was analyzed in a prospective 12-month window, a worsening of physical function and general health status was observed; notwithstanding, antiandrogens remained signif icantly associated to a better QOL than LHRH-analogue therapies also o\er time: a favourable physical function and general health status appeared again to be related to cyproterone acetate than bicalutamide. Conclusions: Androgen deprivation therapy is associated with decline in QOL, particularly in the domains of physical function, energy, and general health status. This survey demonstrated that antiandrogens had a better QOL profile than LHRH-analogue containing therapies; furthermore, a more favourable tolerability for cyproterone acetate as compared to bicalutamide is suggested.
Quality of life evaluation by EORTC QLQ-C30 questionnaire in patients treated with hormonal treatment in Italy : A QUABIOS group study / D. Prezioso, R. Bartoletti, M. Cecchi, V. Cicalese, S. Cosciani Cunico, R. Damiano, A. De Lisa, N. Franzolin, B. Frea, G. Guazzoni, E. Mearini, G. Morgia, G. Muzzonigro, G. Oliva, F. Orestano, A. Pagliarulo, G. Pappagallo, P. Parma, M. Perachino, P. Pompa, F. Rocco, F. Zattoni, Q. Study Group. - In: ARCHIVIO ITALIANO DI UROLOGIA ANDROLOGIA. - ISSN 1124-3562. - 79:3(2007), pp. 99-103.
Quality of life evaluation by EORTC QLQ-C30 questionnaire in patients treated with hormonal treatment in Italy : A QUABIOS group study
F. Rocco;
2007
Abstract
Objectives: An observational study was planned by the QwABIOS group, to survey the hormonal treatment administered to prostate cancer patients in Italy within a time win dow of 12 months. We report here a prospective quality of life (QOL) evaluation over time and by hormonal treatment modalities. Methods: Patients with diagnosis of prostate cancer and treated with hormonal therapy were eligible for thh study. The EORTC QLQ-C30 v.3 questionnaire was administered at enrol ment, after 6 months and after 12 months from enrolment. Results: 587 patients were enrolled by 33 urological centers. When 1518 vuits were considered together independently of time, antiandrogen monotherapy was associated with a significantly bet ter QOL than LHRH-analogue containing treatment modalities in almost all functional scales; cyproterone acetate demonstrated a better physical function and general health status than bica lutamide. When QOL was analyzed in a prospective 12-month window, a worsening of physical function and general health status was observed; notwithstanding, antiandrogens remained signif icantly associated to a better QOL than LHRH-analogue therapies also o\er time: a favourable physical function and general health status appeared again to be related to cyproterone acetate than bicalutamide. Conclusions: Androgen deprivation therapy is associated with decline in QOL, particularly in the domains of physical function, energy, and general health status. This survey demonstrated that antiandrogens had a better QOL profile than LHRH-analogue containing therapies; furthermore, a more favourable tolerability for cyproterone acetate as compared to bicalutamide is suggested.Pubblicazioni consigliate
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