Newly synthesized mono-, di-, and triphosphate of 2-alkynyl adenosines showed very different behavior in human platelet P2Y receptor models, according to the different alkynyl chains. In fact, 2-hexynyladenosine di- (5) and triphosphate (7) induced platelet shape change and aggregation and inhibited PGE(1)-induced increase in platelet cyclic AMP. On the contrary, the corresponding 2-phenylethynyladenosine di- (6) and triphosphate (8) did not induce platelet shape change or aggregation, but inhibited platelet aggregation induced by ADP.
Effects of 5'-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors / G. Cristalli, G.M. Podda, S. Costanzi, C. Lambertucci, A. Lecchi, S. Vittori, R. Volpini, M.L. Zighetti, M. Cattaneo. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 48:8(2005 Apr 21), pp. 2763-2766.
|Titolo:||Effects of 5'-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors|
CATTANEO, MARCO NATALE (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||21-apr-2005|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1021/jm0493562|
|Appare nelle tipologie:||01 - Articolo su periodico|