Low plasma vitamin B6, measured as pyridoxal-5′-phosphate (PLP), is associated with an increased risk of first venous thromboembolism (VTE). In a prospective cohort of 757 patients with first VTE we investigated the association of PLP levels with risk of recurrent VTE. After 4 years, the likelihood of VTE recurrence was 22.5% (95% CI 13.6-31.5%) among patients with PLP ≤23.3 nmol/L and 14.4% (11.5-17.4%) among those with PLP >23.3 nmol/L (p=0.01). Patients with PLP ≤23.3 nmol/L had 1.8-fold higher recurrence risk (1.01-3.14) than patients with PLP >23.3 nmol/L (adjusted for confounders including homocysteine). Therefore, low vitamin B6 is a risk factor of recurrent VTE.
|Titolo:||Low vitamin B6 levels and the risk of recurrent venous thromboembolism|
CATTANEO, MARCO NATALE (Ultimo)
|Parole Chiave:||Deep vein thrombosis; Homocysteine; Pulmonary embolism; Risk factors; Vitamin B6|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||set-2007|
|Digital Object Identifier (DOI):||10.3324/haematol.11318|
|Appare nelle tipologie:||01 - Articolo su periodico|