Low plasma vitamin B6, measured as pyridoxal-5′-phosphate (PLP), is associated with an increased risk of first venous thromboembolism (VTE). In a prospective cohort of 757 patients with first VTE we investigated the association of PLP levels with risk of recurrent VTE. After 4 years, the likelihood of VTE recurrence was 22.5% (95% CI 13.6-31.5%) among patients with PLP ≤23.3 nmol/L and 14.4% (11.5-17.4%) among those with PLP >23.3 nmol/L (p=0.01). Patients with PLP ≤23.3 nmol/L had 1.8-fold higher recurrence risk (1.01-3.14) than patients with PLP >23.3 nmol/L (adjusted for confounders including homocysteine). Therefore, low vitamin B6 is a risk factor of recurrent VTE.
Low vitamin B6 levels and the risk of recurrent venous thromboembolism / G. Hron, R. Lombardi, S. Eichinger, A. Lecchi, P.A. Kyrle, M. Cattaneo. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 92:9(2007 Sep), pp. 1250-1253.
Low vitamin B6 levels and the risk of recurrent venous thromboembolism
M. CattaneoUltimo
2007
Abstract
Low plasma vitamin B6, measured as pyridoxal-5′-phosphate (PLP), is associated with an increased risk of first venous thromboembolism (VTE). In a prospective cohort of 757 patients with first VTE we investigated the association of PLP levels with risk of recurrent VTE. After 4 years, the likelihood of VTE recurrence was 22.5% (95% CI 13.6-31.5%) among patients with PLP ≤23.3 nmol/L and 14.4% (11.5-17.4%) among those with PLP >23.3 nmol/L (p=0.01). Patients with PLP ≤23.3 nmol/L had 1.8-fold higher recurrence risk (1.01-3.14) than patients with PLP >23.3 nmol/L (adjusted for confounders including homocysteine). Therefore, low vitamin B6 is a risk factor of recurrent VTE.Pubblicazioni consigliate
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