The immunogenicity of an anti-influenza vaccine was assessed in 409 former intravenous drug user volunteers and its effect on the levels of HIV-1 RNA, proviral DNA and on CD4+ lymphocyte counts in a subset HIV-1-positive subjects was measured. HIV-1-positive individuals (n = 72) were divided into three groups on the basis of their CD4+ lymphocyte counts, while the 337 HIV-1-negative participants were allocated into group four. Haemagglutination inhibiting (HI) responses varied from 45.8 to 70% in the HIV-1-positive subjects and were significantly higher in group four (80.7% responses to the H1N1 strain, 81.6% to the H3N2 strain, and 83% to the B strain). The percentage of subjects with HI protective antibody titres (> or = 1:40) increased significantly after vaccination, especially in HIV-1 uninfected subjects. Immunization caused no significant changes in CD4+ counts and in neither plasma HIV-1 RNA nor proviral DNA levels. Therefore, vaccination against influenza may benefit persons infected by HIV-1.
Influenza vaccination of HIV-1-positive and HIV-1-negative former intravenous drug users / A. Amendola, A. Boschini, D. Colzani, G. Anselmi, A. Oltolina, R. Zucconi, M. Begnini, S. Besana, E. Tanzi, A.R. Zanetti. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 0146-6615. - 65:4(2001 Dec), pp. 644-648.
|Titolo:||Influenza vaccination of HIV-1-positive and HIV-1-negative former intravenous drug users|
AMENDOLA, ANTONELLA (Primo)
TANZI, ELISABETTA (Penultimo)
ZANETTI, ALESSANDRO REMO (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale e Applicata|
|Data di pubblicazione:||dic-2001|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/jmv.2085|
|Appare nelle tipologie:||01 - Articolo su periodico|