Long non coding RNAs (lncRNAs) are defined as ncRNAs of more than 200 nt in length. They are involved in a large spectrum of biological processes, such as maintenance of genome integrity, genomic imprinting, cell differentiation, and development by means of mechanisms that remain to be fully elucidated. Besides their role in normal cellular physiology, accumulating evidence has linked lncRNA expression and functions to cancer development and progression. In this review, we summarize and discuss what is known about their expression and roles in hematopoiesis with a particular focus on their cell-type speciï¬city, functional interactions, and involvement in the pathobiology of hematological malignancies.
Long non-coding RNAs in normal and malignant hematopoiesis / L. Nobili, M. Lionetti, A. Neri. - In: ONCOTARGET. - ISSN 1949-2553. - 7:31(2016), pp. 50666-50681.
|Titolo:||Long non-coding RNAs in normal and malignant hematopoiesis|
NOBILI, RITA LUCIA (Primo)
LIONETTI, MARTA (Secondo)
NERI, ANTONINO (Ultimo)
|Parole Chiave:||hematological malignancies; hematopoiesis; long noncoding RNAs; transcriptional regulation; translation regulation|
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
|Data di pubblicazione:||2016|
|Data ahead of print / Data di stampa:||11-mag-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.18632/oncotarget.9308|
|Appare nelle tipologie:||01 - Articolo su periodico|